A Trigger for Opioid Misuse: Chronic Pain and Stress Dysregulate the Mesolimbic Pathway and Kappa Opioid System
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چکیده
منابع مشابه
A Trigger for Opioid Misuse: Chronic Pain and Stress Dysregulate the Mesolimbic Pathway and Kappa Opioid System
Pain and stress are protective mechanisms essential in avoiding harmful or threatening stimuli and ensuring survival. Despite these beneficial roles, chronic exposure to either pain or stress can lead to maladaptive hormonal and neuronal modulations that can result in chronic pain and a wide spectrum of stress-related disorders including anxiety and depression. By inducing allostatic changes in...
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This issue of American Family Physician features a summary of the American Academy of Family Physicians’ (AAFP’s) updated position paper on opioid abuse and pain management.1 Chronic pain and opioid misuse have intersected as significant public health crises, and family physicians deserve the most accurate guidance to address these issues. Despite growing concerns about overprescribing of opioi...
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OBJECTIVE The crisis of prescription opioid (PO) related harms has focused attention toward identifying and treating high-risk populations. This review aims to synthesize systematic reviews on the epidemiology and clinical management of comorbid chronic pain and PO or other substance misuse. METHODS A systematic database search was conducted to identify systematic reviews published between 20...
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The recent review by Vowles et al. 5 on the rates of opioid misuse, abuse, and addiction in chronic pain is a sorely needed step in the right direction toward better defining and understanding the prevalence of opioid misuse, abuse, and addiction among individuals with chronic pain. The authors are to be applauded for both synthesizing and advocating for literature using explicit definitions of...
متن کاملChronic back pain with possible prescription opioid misuse.
IMPORTANCE Data on the effectiveness and safety of long-term opioid therapy for chronic pain are limited. Opioid adherence monitoring includes urine drug testing. Determining whether a patient's opioid prescription should be discontinued after an unexpected urine test result can be clinically complex. OBJECTIVE To review safe opioid prescribing practices and appropriate interpretation and man...
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ژورنال
عنوان ژورنال: Frontiers in Neuroscience
سال: 2016
ISSN: 1662-453X
DOI: 10.3389/fnins.2016.00480